RET-DEPENDENT AND RET-INDEPENDENT MECHANISMS OF GFL-INDUCED ENHANCEMENT IN THE CAPSAICIN STIMULATED-RELEASE OF iCGRP FROM SENSORY NEURONS
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چکیده
منابع مشابه
Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization
BACKGROUND The GDNF family ligands (GFLs) are regulators of neurogenic inflammation and pain. We have previously shown that GFLs increase the release of the sensory neuron neuropeptide, calcitonin gene-related peptide (CGRP) from isolated mouse DRG. RESULTS Inhibitors of the mitogen-activated protein kinase (MAPK) pathway abolished the enhancement of CGRP release by GDNF. Neurturin-induced en...
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تاریخ انتشار 2009